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| St. Louis Rams | Pos | Injury | Status | | Jerome Carter | S | | IR | | Adam Goldberg | G | Knee | IR | | Dante Hall | WR | Ankle | IR | | Tye Hill | CB | Wrist | IR | | Richie Incognito | G | Knee | IR | | Leonard Little | DE | Toe | IR | | Orlando Pace | T | | IR | | Mark Setterstrom | G | ACL | IR | | Robert Smith | RB | Knee | IR | | Pisa Tinoisamoa | LB | | IR | | Aaron Walker | TE | | IR | | Brandon Chillar | LB | Lower Leg | Questionable | | Arizona Cardinals | Pos | Injury | Status | | Bertrand Berry | DE | Triceps | IR | | Eric Green | CB | Groin | IR | | Ross Kolodziej | DT | Knee | IR | | Matt Leinart | QB | Collarbone | IR | | Ahmad Merritt | WR | Ankle | IR | | Chike Okeafor | DE | | IR | | Leonard Pope | TE | Ankle | IR | | Oliver Ross | G | Tricept | IR | | Adrian Wilson | S | Heel | IR | | Anquan Boldin | WR | Toe | Questionable | | Larry Fitzgerald | WR | Groin | Questionable | | Nathan Hodel | TE | Ankle | Questionable |
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| Seattle Seahawks | Pos | Injury | Status | | Chartric Darby | DT | Knee | IR | | Alvin Pearman | RB | Knee | IR | | Marcus Tubbs | DT | ACL | IR | | C.J. Wallace | S | Knee | IR | | Deion Branch | WR | Calf | Questionable | | Walter Jones | T | Shoulder | Questionable | | Atlanta Falcons | Pos | Injury | Status | | Roderick Coleman | DT | Arm | IR | | Doug Datish | C | Wrist | IR | | Jamin Elliott | WR | Knee | IR | | Brian Finneran | WR | Knee | IR | | Renardo Foster | OL | Knee | IR | | Wayne Gandy | T | Knee | IR | | Trey Lewis | DT | Knee | IR | | Omare Lowe | CB | | IR | | Martrez Milner | TE | Ankle | IR | | David Patterson | DL | | IR | | Terrance Pennington | T | | IR | | Lewis Sanders | DB | | IR | | D.J. Shockley | QB | Knee | IR | | Todd Weiner | T | Knee | IR | | David Irons | CB | Hamstring | Questionable | | Michael Jenkins | WR | Quadricep | Questionable | | Lawyer Milloy | S | Hip | Questionable | | Michael Vick | QB | | Suspended |
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| Pittsburgh Steelers | Pos | Injury | Status | | Ryan Clark | S | Spleen | IR | | Dan Kreider | RB | Knee | IR | | Willie Parker | RB | Leg | IR | | Aaron Smith | DE | Biceps | IR | | Jerame Tuman | TE | Back | IR | | Ben Roethlisberger | QB | Ankle | Questionable | | Allen Rossum | CB | Hamstring | Questionable | | Baltimore Ravens | Pos | Injury | Status | | Prescott Burgess | LB | Quad | IR | | Dan Cody | DE | Knee | IR | | P.J. Daniels | RB | Hamstring | IR | | Todd Heap | TE | Hamstring | IR | | Chris McAlister | CB | Knee | IR | | Steve McNair | QB | | IR | | Trevor Pryce | DT | Chest | IR | | Samari Rolle | CB | | IR | | B.J. Sams | RB | Knee | IR | | Gerome Sapp | S | Thigh | IR | | Mike Smith | LB | Knee | IR | | Mike Anderson | RB | Thigh | Questionable | | Mark Clayton | WR | Back | Questionable | | Ray Lewis | LB | Back | Questionable |
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| New Orleans Saints | Pos | Injury | Status | | McKinley Boykin | DT | | IR | | Jamaal Branch | RB | | IR | | Mark Campbell | TE | Back | IR | | Steve Gleason | S | Knee | IR | | Olindo Mare | K | Hip | IR | | Deuce McAllister | RB | ACL | IR | | Mike McKenzie | CB | | IR | | Brian Young | DE | Illness | IR | | Aaron Stecker | RB | Toe | Questionable | | Chicago Bears | Pos | Injury | Status | | Anthony Adams | DT | Elbow | IR | | Mark Anderson | DE | Knee | IR | | Dan Bazuin | DE | | IR | | Cedric Benson | RB | | IR | | Mike Brown | S | ACL | IR | | Ruben Brown | G | | IR | | Dusty Dvoracek | DT | ACL | IR | | Antonio Garay | DE | Ankle | IR | | Ade Jimoh | CB | | IR | | Michael Okwo | LB | Shoulder | IR | | Kevin Payne | S | | IR | | P.J. Pope | RB | | IR | | J.D. Runnels | RB | | IR | | Nathan Vasher | CB | | IR | | Lance Briggs | LB | Hip | Questionable | | Rex Grossman | QB | Knee | Questionable |
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| San Francisco 49ers | Pos | Injury | Status | | C.J. Brewer | WR | ACL | IR | | Joe Cohen | DE | MCL | IR | | Jonas Jennings | T | | IR | | Manny Lawson | LB | | IR | | Jay Moore | DE | Ankle | IR | | Justin Smiley | G | | IR | | Alex Smith | QB | Shoulder | IR | | B.J. Tucker | CB | | IR | | Melvin Oliver | DE | | PUP | | Marcus Hudson | CB | Knee | Questionable | | Michael Robinson | RB | Shoulder | Questionable | | Derek Smith | LB | Shoulder | Questionable | | Cleveland Browns | Pos | Injury | Status | | Mike Adams | CB | | IR | | Gary Baxter | CB | Knee | IR | | Kris Griffin | LB | Knee | IR | | Efrem Hill | WR | | IR | | Ethan Kelley | DT | Knee | IR | | Seth McKinney | C | Shoulder | IR | | Justin Sandy | S | | IR | | Matt Stewart | LB | | IR | | Ted Washington | DT | Knee | IR | | LeCharles Bentley | C | | PUP | | Joe Jurevicius | WR | Knee | Questionable | | Antwan Peek | LB | Ankle | Questionable | | Orpheus Roye | DE | Knee | Questionable |
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| Minnesota Vikings | Pos | Injury | Status | | Rufus Alexander | LB | | IR | | Erasmus James | DE | Knee | IR | | Darrion Scott | DE | | IR | | Sidney Rice | WR | Ankle | Questionable | | Dontarrious Thomas | LB | Groin | Questionable | | Pat Williams | DT | Knee | Questionable | | Antoine Winfield | CB | Shoulder | Questionable | | Ray Edwards | DE | | Suspended | | Denver Broncos | Pos | Injury | Status | | Stephen Alexander | TE | Calf | IR | | Ebenezer Ekuban | DE | Achilles | IR | | Nick Ferguson | S | Knee | IR | | Ben Hamilton | C | Concussion | IR | | Warrick Holdman | LB | Spinal Cord | IR | | Nate Jackson | TE | Groin | IR | | Jarvis Moss | DE | Leg | IR | | Tom Nalen | C | Biceps | IR | | Rod Smith | WR | | PUP | | Ian Gold | LB | Knee | Questionable | | Daniel Graham | TE | Ankle | Questionable | | Brandon Stokley | WR | Knee | Questionable |
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| Detroit Lions | Pos | Injury | Status | | Idrees Bashir | S | Knee | IR | | Daniel Bullocks | S | | IR | | Brian Calhoun | RB | Knee | IR | | Dan Campbell | TE | Elbow | IR | | Frank Davis | OL | | IR | | John Deraney | K | | IR | | LaMarcus Hicks | DB | Ankle | IR | | Jonathan Scott | T | Hand | IR | | Drew Stanton | QB | Knee | IR | | Roy Williams | WR | Knee | IR | | Stanley Wilson | CB | Knee | IR | | Devale Ellis | WR | | PUP | | Tatum Bell | RB | Foot | Questionable | | Troy Walters | WR | Concussion | Questionable | | Green Bay Packers | Pos | Injury | Status | | Colin Cole | DT | Arm | IR | | Tyrone Culver | S | | IR | | Noah Herron | RB | | IR | | Abdul Hodge | LB | | IR | | Carlyle Holiday | WR | Knee | IR | | Tory Humphrey | TE | | IR | | Johnny Jolly | DT | Shoulder | IR | | Tony Palmer | G | Neck | IR | | Ryan Powdrell | FB | | IR | | Tyson Walter | T | | IR | | DeShawn Wynn | RB | Shoulder | IR | | Greg Jennings | WR | Ankle | Questionable | | Ryan Pickett | DT | Groin | Questionable |
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| Jacksonville Jaguars | Pos | Injury | Status | | John Broussard | WR | Ankle | IR | | Greg Estandia | TE | Shoulder | IR | | Tony Gilbert | LB | | IR | | Tony McDaniel | DT | Wrist | IR | | Stockar McDougle | T | | IR | | Chris Naeole | G | Quadriceps | IR | | Gerald Sensabaugh | S | Shoulder | IR | | Brian Smith | DE | Hip | IR | | Marcus Stroud | DT | Ankle | IR | | Mike Walker | WR | Knee | IR | | George Wrighster | TE | ACL | IR | | James Wyche | DE | Groin | IR | | Houston Texans | Pos | Injury | Status | | Jon Abbate | LB | | IR | | Roc Alexander | CB | Knee | IR | | Shawn Barber | LB | Neck | IR | | Glenn Earl | S | | IR | | Ahman Green | RB | Knee | IR | | Brandon Harrison | S | | IR | | Scott Jackson | OL | | IR | | Cedric Killings | DT | Neck | IR | | Jerome Mathis | WR | Foot | IR | | Steve McKinney | G | ACL | IR | | Dunta Robinson | CB | Knee | IR | | Jason Simmons | CB | Knee | IR | | Chris Taylor | RB | Knee | IR | | Fred Weary | C | Leg | IR | | Chris White | C | Knee | IR | | Charles Spencer | T | | PUP | | Danny Clark | LB | Groin | Questionable | | Matt Schaub | QB | Shoulder | Questionable |
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| Tennessee Titans | Pos | Injury | Status | | Ken Amato | C | | IR | | Jacob Ford | DE | | IR | | Ryan Fowler | LB | Shoulder | IR | | Chris Hope | S | Concussion | IR | | Antonio Johnson | DT | Knee | IR | | Brandon Jones | WR | Groin | IR | | Eric King | CB | | IR | | David Givens | WR | | PUP | | Gilbert Gardner | LB | Calf | Questionable | | Nick Harper | CB | Groin | Questionable | | Kevin Mawae | G | Calf | Questionable | | Benji Olson | G | Back | Questionable | | Pacman Jones | CB | | Suspended | | Indianapolis Colts | Pos | Injury | Status | | Daniel Federkeil | OT | Concussion | IR | | Dwight Freeney | DE | Foot | IR | | Roy Hall | WR | | IR | | Daymeion Hughes | CB | | IR | | Anthony McFarland | DT | Knee | IR | | Aaron Moorehead | WR | Back | IR | | Rob Morris | LB | ACL | IR | | Mike Seidman | TE | Knee | IR | | Antonio Smith | DB | | IR | | Victor Worsley | LB | Foot | IR | | Antoine Bethea | CB | Knee | Questionable | | Anthony Gonzalez | WR | Foot | Questionable | | Marvin Harrison | WR | Knee | Questionable | | Tim Jennings | CB | Concussion | Questionable | | Robert Mathis | DE | Knee | Questionable | | Quinn Pitcock | DT | Groin | Questionable | | Keiwan Ratliff | CB | Hamstring | Questionable | | Ben Utecht | TE | Shoulder | Questionable |
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| Cincinnati Bengals | Pos | Injury | Status | | Ahmad Brooks | LB | | IR | | Dan Burks | RB | | IR | | DeDe Dorsey | RB | | IR | | Aaron Elling | K | | IR | | Eric Ghiaciuc | C | | IR | | Eric Henderson | LB | Wrist | IR | | Kenny Irons | RB | ACL | IR | | Herana-Da Jones | S | Knee | IR | | Adam Kieft | T | | IR | | Ethan Kilmer | WR | Knee | IR | | Lemar Marshall | LB | Achilles | IR | | Caleb Miller | LB | Back | IR | | Tab Perry | WR | Hip | IR | | Brandon Williams | CB | | IR | | Madieu Williams | S | | IR | | Chris Perry | RB | | PUP | | David Pollack | DE | Neck | PUP | | Willie Anderson | T | Hamstring | Questionable | | T.J. Houshmandzadeh | WR | Ankle | Questionable | | Odell Thurman | LB | | Suspended | | Miami Dolphins | Pos | Injury | Status | | Yeremiah Bell | S | Achilles | IR | | Ronnie Brown | RB | ACL | IR | | Channing Crowder | LB | Knee | IR | | Andre Goodman | CB | | IR | | Trent Green | QB | Concussion | IR | | Renaldo Hill | CB | ACL | IR | | Drew Mormino | C | Shoulder | IR | | Chase Page | DT | | IR | | Mike Rosenthal | G | Shoulder | IR | | Zach Thomas | LB | Migraine | IR | | Travares Tillman | S | Knee | IR | | Ricky Williams | RB | Shoulder | IR | | Cameron Worrell | S | Knee | IR | | Abraham Wright | LB | Knee | IR | | Joe Toledo | T | | PUP | | Travis Daniels | CB | Ankle | Questionable | | Jason Taylor | DE | Foot | Questionable |
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| New England Patriots | Pos | Injury | Status | | Rosevelt Colvin | LB | Foot | IR | | Oscar Lua | LB | Knee | IR | | Sammy Morris | RB | Chest | IR | | Mike Richardson | DB | Arm | IR | | Chad Scott | CB | Knee | IR | | David Thomas | TE | | IR | | Mike Wright | DT | Foot | IR | | Willie Andrews | DB | Foot | Questionable | | Stephen Neal | T | Shoulder | Questionable | | Ben Watson | TE | Ankle | Questionable | | Billy Yates | G | Foot | Questionable | | New York Giants | Pos | Injury | Status | | Adrian Awasom | DE | | IR | | Dek Bake | DL | | IR | | Robert Douglas | RB | Knee | IR | | James Finn | RB | Shoulder | IR | | Michael Jennings | WR | | IR | | Darcy Johnson | TE | Knee | IR | | William Joseph | DT | Back | IR | | Mathias Kiwanuka | LB | Leg | IR | | Ryan Kuehl | DT | | IR | | Todd Londot | C | | IR | | Jeremy Shockey | TE | Leg | IR | | Derrick Ward | RB | Leg | IR | | Ahmad Bradshaw | RB | Calf | Questionable | | Manuel Wright | DT | Ankle | Questionable |
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| Kansas City Chiefs | Pos | Injury | Status | | Johnny Baldwin | LB | Knee | IR | | Chris Bober | T | | IR | | Tyron Brackenridge | DB | | IR | | Larry Johnson | RB | | IR | | Rudy Niswanger | OL | | IR | | Maurice Price | WR | | IR | | Tyler Thigpen | QB | Knee | IR | | Pat Thomas | LB | | IR | | Kyle Turley | T | Back | IR | | Donnie Edwards | LB | Hamstring | Questionable | | Napoleon Harris | LB | Knee | Questionable | | New York Jets | Pos | Injury | Status | | Laveranues Coles | WR | Ankle | IR | | James Ihedigbo | DB | | IR | | Justin Miller | CB | Knee | IR | | Chansi Stuckey | WR | Foot | IR | | Jason Trusnik | LB | | IR | | Stacy Tutt | FB | | IR | | Jonathan Vilma | LB | Knee | IR | | Chris Baker | TE | Back | Questionable | | Kellen Clemens | QB | Ribs | Questionable | | James Dearth | TE | Foot | Questionable | | Shaun Ellis | DE | Shoulder | Questionable | | Nick Mangold | C | Player Decision | Questionable | | Brandon Moore | G | Neck | Questionable | | DeWayne Robertson | DT | Knee | Questionable | | Brad Smith | WR | Back | Questionable |
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| San Diego Chargers | Pos | Injury | Status | | Tyronne Gross | RB | Knee | IR | | Eric Parker | WR | Toe | IR | | Carlos Polk | LB | Shoulder | IR | | Germaine Race | RB | | IR | | Oakland Raiders | Pos | Injury | Status | | Jarrod Cooper | S | Knee | IR | | Daunte Culpepper | QB | | IR | | Justin Fargas | RB | | IR | | Cornell Green | T | | IR | | Jake Grove | C | Knee | IR | | Johnathan Holland | WR | | IR | | Tommy Kelly | DT | Knee | IR | | ReShard Lee | RB | | IR | | Fred Wakefield | TE | Knee | IR | | Michael Bush | RB | | PUP | | Jon Alston | LB | Calf | Questionable | | Tim Dwight | WR | Hamstring | Questionable |
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| Buffalo Bills | Pos | Injury | Status | | Copeland Bryan | DE | | IR | | Ryan Denney | DE | | IR | | Kevin Everett | TE | Cervical Spine | IR | | Kevin Harrison | LB | Knee | IR | | Aaron Merz | G | Shoulder | IR | | Matt Murphy | TE | Calf | IR | | Paul Posluszny | LB | Forearm | IR | | Peerless Price | WR | Neck | IR | | Derek Schouman | RB | Ankle | IR | | Ko Simpson | S | Ankle | IR | | Anthony Thomas | RB | | IR | | Kiwaukee Thomas | CB | Groin | IR | | Al Wallace | DE | | IR | | Jason Webster | CB | | IR | | Jason Whittle | T | Hamstring | IR | | George Wilson | S | Ribs | IR | | Coy Wire | S | | IR | | Josh Reed | WR | Back | Questionable | | Donte Whitner | S | Illness | Questionable | | Philadelphia Eagles | Pos | Injury | Status | | Sean Considine | S | Shoulder | IR | | Jerome McDougle | DE | Triceps | IR | | Ryan Moats | RB | Ankle | IR | | Stefan Rodgers | T | Foot | IR | | Ian Scott | DT | | IR | | Takeo Spikes | LB | Rotator Cuff | IR |
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| Carolina Panthers | Pos | Injury | Status | | Brett Basanez | QB | Wrist | IR | | Keary Colbert | WR | Knee | IR | | Jake Delhomme | QB | Elbow | IR | | Curtis Deloatch | CB | ACL | IR | | Nick Goings | RB | Concussion | IR | | Justin Hartwig | G | | IR | | Terrence Melton | LB | Knee | IR | | Dan Morgan | LB | Achilles | IR | | Julius Peppers | DE | | IR | | Nate Salley | S | Knee | IR | | Dante Wesley | CB | Collarbone | IR | | Tampa Bay Buccaneers | Pos | Injury | Status | | Mike Alstott | RB | Neck | IR | | Charles Bennett | LB | Knee | IR | | Antoine Cash | LB | Knee | IR | | Torrie Cox | CB | Knee | IR | | Chris Denman | T | | IR | | Mark Jones | WR | Knee | IR | | Sam Olajubutu | LB | Achilles | IR | | Luke Petitgout | T | Knee | IR | | Sabby Piscitelli | S | Foot | IR | | Chris Simms | QB | Spleen | IR | | Maurice Stovall | WR | Arm | IR | | Paris Warren | WR | | IR | | Cadillac Williams | RB | Patella | IR | | B.J. Askew | RB | Ankle | Questionable | | Patrick Chukwurah | LB | Hamstring | Questionable | | Earnest Graham | RB | Ankle | Questionable | | Ike Hilliard | WR | Knee | Questionable | | Brian Kelly | CB | Knee | Questionable | | Ryan Nece | LB | Groin | Questionable | | Michael Pittman | RB | Ankle | Questionable | | Greg White | DE | Quadricep | Questionable |
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| Dallas Cowboys | Pos | Injury | Status | | Deon Anderson | FB | | IR | | Jason Ferguson | DT | Bicep | IR | | Washington Redskins | Pos | Injury | Status | | Nehemiah Broughton | RB | | IR | | Tyler Ecker | TE | | IR | | Mike Espy | WR | | IR | | Steven Harris | WR | Knee | IR | | Jon Jansen | T | Ankle | IR | | Brandon Lloyd | WR | Collarbone | IR | | Roger Mcintosh | LB | Knee | IR | | Mike Pucillo | G | | IR | | Carlos Rogers | DB | Knee | IR | | Ross Tucker | T | | IR |
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